Life comes with seasons—joyful ones and hard ones, moments of peace and storms of uncertainty. In all these moments, one thing remains vital: prayer. When we feel strong or weak, encouraged or discouraged, the Bible encourages us to pray in season and out of season.
That means praying when it’s easy and when it’s not. When everything is going well and when nothing makes sense.
This kind of prayer life keeps us grounded, connected to God, and spiritually strong. It’s not about having perfect words—it’s about staying in relationship with our Creator no matter what we’re going through.
Below are 35 Scripture passages that highlight this call to persistent and faithful prayer.
Key Takeaways:
- Prayer isn’t just for crisis moments—it’s for all times.
- The Bible shows us that communication with God should be continuous.
- When we stay in prayer, we stay connected to God’s peace, strength, and wisdom.
1. 2 Timothy 4:2
Preach the word; be prepared in season and out of season; correct, rebuke and encourage—with great patience and careful instruction.
Explanation: Though this verse focuses on preaching, it also teaches consistency in spiritual disciplines—like prayer—no matter the timing or circumstance.
2. 1 Thessalonians 5:17
Pray continually.
Explanation: A simple but powerful command—prayer should be ongoing and constant, not just occasional.
3. Ephesians 6:18
And pray in the Spirit on all occasions with all kinds of prayers and requests.
Explanation: This verse urges us to pray at all times and in all ways, covering every area of life through prayer.
4. Colossians 4:2
Devote yourselves to prayer, being watchful and thankful.
Explanation: Prayer should be a regular commitment, with an attitude of alertness and gratitude.
5. Romans 12:12
Be joyful in hope, patient in affliction, faithful in prayer.
Explanation: Consistency in prayer strengthens us in all seasons—whether we’re hoping, suffering, or rejoicing.
6. Luke 18:1
Then Jesus told his disciples a parable to show them that they should always pray and not give up.
Explanation: Jesus made it clear: persistent prayer is essential, especially when we feel like quitting.
7. Philippians 4:6
Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God.
Explanation: Prayer should be our first response to every worry, in every situation.
8. James 5:13
Is anyone among you in trouble? Let them pray. Is anyone happy? Let them sing songs of praise.
Explanation: Prayer is the answer for both good and difficult times—joy and trouble alike.
9. Psalm 55:17
Evening, morning and noon I cry out in distress, and he hears my voice.
Explanation: David shows us a pattern of regular, daily prayer no matter how he feels.
10. Mark 1:35
Very early in the morning, while it was still dark, Jesus got up, left the house and went off to a solitary place, where he prayed.
Explanation: Even Jesus set aside time in every season of life to pray—His example teaches us to do the same.
11. Psalm 34:15
The eyes of the Lord are on the righteous, and his ears are attentive to their cry.
Explanation: God is always listening—our prayers are never ignored.
12. Matthew 6:6
But when you pray, go into your room, close the door and pray to your Father, who is unseen.
Explanation: Intimate, regular prayer is encouraged—even when no one else sees.
13. 1 Peter 5:7
Cast all your anxiety on him because he cares for you.
Explanation: God invites us to unload our burdens through prayer, anytime.
14. Jeremiah 29:12
Then you will call on me and come and pray to me, and I will listen to you.
Explanation: God promises to hear us when we genuinely reach out to Him.
15. Psalm 145:18
The Lord is near to all who call on him, to all who call on him in truth.
Explanation: Prayer draws us close to God—and He responds with nearness.
16. Matthew 26:41
Watch and pray so that you will not fall into temptation.
Explanation: Regular prayer strengthens us to stand firm against temptation.
17. Hebrews 4:16
Let us then approach God’s throne of grace with confidence.
Explanation: We’re invited to come boldly to God at all times—He welcomes us.
18. Jonah 2:1
From inside the fish Jonah prayed to the Lord his God.
Explanation: Even in the darkest place, prayer still reaches God’s ears.
19. Psalm 116:2
Because he turned his ear to me, I will call on him as long as I live.
Explanation: God’s faithfulness motivates us to keep calling on Him always.
20. Acts 2:42
They devoted themselves to the apostles’ teaching and to fellowship, to the breaking of bread and to prayer.
Explanation: The early church modeled consistent and collective prayer life.
21. Luke 6:12
One of those days Jesus went out to a mountainside to pray, and spent the night praying to God.
Explanation: Jesus showed the importance of extended, focused prayer—even in busy seasons.
22. Psalm 5:3
In the morning, Lord, you hear my voice; in the morning I lay my requests before you.
Explanation: Starting the day with prayer sets the tone for everything else.
23. Romans 8:26
The Spirit helps us in our weakness. We do not know what we ought to pray for, but the Spirit himself intercedes for us.
Explanation: Even when we don’t know what to say, the Holy Spirit steps in.
24. 1 Samuel 1:27
I prayed for this child, and the Lord has granted me what I asked of him.
Explanation: Hannah’s story shows the power of prayer through seasons of waiting and heartbreak.
25. Psalm 42:8
By day the Lord directs his love, at night his song is with me—a prayer to the God of my life.
Explanation: Prayer isn’t limited by time—it flows day and night as part of our relationship with God.
26. James 5:16
The prayer of a righteous person is powerful and effective.
Explanation: Don’t underestimate prayer—it has real impact and power.
27. Daniel 6:10
He got down on his knees and prayed, giving thanks to his God, just as he had done before.
Explanation: Even under pressure, Daniel kept praying just as he always had. Prayer was his habit.
28. 1 Chronicles 16:11
Look to the Lord and his strength; seek his face always.
Explanation: Always seeking God through prayer strengthens us for any season.
29. Nehemiah 1:6
Let your ear be attentive and your eyes open to hear the prayer your servant is praying before you day and night.
Explanation: Nehemiah prayed with passion and persistence—day and night.
30. Psalm 141:2
May my prayer be set before you like incense; may the lifting up of my hands be like the evening sacrifice.
Explanation: Prayer is a sacred offering to God, worthy of daily devotion.
31. Acts 16:25
About midnight Paul and Silas were praying and singing hymns to God, and the other prisoners were listening to them.
Explanation: Even in prison, they chose to pray and praise—showing faith in every season.
32. Psalm 62:8
Trust in him at all times, you people; pour out your hearts to him.
Explanation: We’re encouraged to open our hearts to God through prayer at all times.
33. Mark 11:24
Whatever you ask for in prayer, believe that you have received it, and it will be yours.
Explanation: Prayer involves not just asking, but believing—trusting in God’s answer.
34. Job 22:27
You will pray to him, and he will hear you, and you will fulfill your vows.
Explanation: Prayer is part of a committed relationship with God that He takes seriously.
35. Zechariah 13:9
They will call on my name and I will answer them.
Explanation: God’s promise is simple and sure—when we call, He answers.
Final Thoughts
The Bible makes it clear—to pray in season and out of season is not just a suggestion, it’s a lifestyle. Whether you’re on a mountaintop or in a valley, God wants to hear from you. These verses show that prayer is powerful, personal, and always needed.
Now it’s your turn. What Bible verse reminds you to pray faithfully in every season? How has prayer carried you through a tough time or helped you celebrate a victory? Share your experiences, favorite verses, or thoughts in the comments—we’d love to hear from you.